The Human Placenta Project

Theme A trending idea Actionable

kathryn.adams kudos icon + kathryn.adams
Within THEME A: BASIC PLACENTA RESEARCH

A1. Identify the most significant recent achievements (technical/understanding) that position the field to gain a deeper understanding of human placenta development and function and support their advancement.

A2. Address the key knowledge gaps that hinder our capability to understand placenta development and function across pregnancy within the maternal/fetal/placenta ecosystem.... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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1 vote
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The Human Placenta Project

Need for a strategic approach to clinical biomarker discovery trending idea

David Weinberg NICHD kudos icon + David Weinberg NICHD
The drug development world has evolved a set of generally agreed upon steps for advancing potential targets forward. This is in part because the end goal - FDA approval and commercial viability drive the requirements and processes. The identification of clinically useful biomarkers is often an outcome of basic research into a biologic process that tangentially is recognized to have clinical utility. Validation processes... more »

Which theme and set of objectives does your response address?

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3 votes
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The Human Placenta Project

Multi-component systems to model the Placenta ecosystem trending idea

David Weinberg NICHD kudos icon + David Weinberg NICHD
The maternal/fetal/placenta ecosystem is complex, with dynamic communication happening among all of the components. Leveraging tissue on a chip technologies one can envision studying interactions of decidua, maternal blood component, immune cells, placenta, etc. to systematically interrogate key interactions. I wonder whether the community feels this is feasible, and also whether iPSC blastoids would be useful in such... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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8 votes
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The Human Placenta Project

Supporting People with Disabilities trending idea

nitkinr kudos icon 2 nitkinr
The National Center for Medical Rehabilitation Research (located within the NICHD) would like to highlight three issues that may arise in the context of the Human Placenta Project:

• Ensure that people with disabilities (PWD) are included among the subject populations – and special efforts are made to support their reproductive health and opportunities. Often, PWD are not asked about reproductive health and are not offered... more »

Which theme and set of objectives does your response address? THEME F: Planning Translation – Hearing all Voices

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4 votes
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The Human Placenta Project

Implantable placental biochemical sensors trending idea

kafox kudos icon 2 kafox
The real-time biolochemical millieu of the devloping placenta is completely unknown. Sensors exist to sample microscopic changes in bioactive compounds in the atmosphere (for environmental health), and small biosensors have been developed to monitor hormonal and biochemical activity in tumors, for example. While not performed in every pregnancy, chorionic villus sampling is performed during pregnancy (removal of placental... more »

Which theme and set of objectives does your response address? THEME G: Envisioning the Future

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6 votes
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The Human Placenta Project

Placental cell units and integrated funtions trending idea

martin-coxca kudos icon 1 martin-coxca
Understanding the placenta from the cell unit constitution and the detailed cell diversity using new tools such as single cell approaches. The complexity of placental functions as a result of the integrated interaction between all trophoblasts subtypes, there is a big gap on the knowledge regarding the exact placental cellular diversity and individual functions (functional nodes). What we know so far and which are the... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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3 votes
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The Human Placenta Project

Simultaneous maternal and fetal blood flow assessment in the placenta using umbilical vein Doppler

Jonathan Rubin kudos icon 1 Jonathan Rubin
A big issue in assessment of placental abnormalities in vivo is that the placenta has two separate blood supplies, maternal and fetal. Presently, there are no easy ways to directly assess these contributing flows at the same time. If there were such a method, it could greatly enhance placental evaluation in a myriad of ways. For instance, it would be possible to show the effects of various therapies on both the maternal... more »

Which theme and set of objectives does your response address? THEME E: Ultrasound

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4 votes
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The Human Placenta Project

Placental Inflammation trending idea

Tamara.Tilburgs kudos icon + Tamara.Tilburgs
Placental inflammation is a key driver of adverse pregnancy events and also directly impacts fetal and neonatal development. A key focus on how inflammatory cells orchestrate immune tolerance and immunity to infection in healthy human placentas as well as how events including infection and allogeneic inflammatory responses contribute to failed trophoblast invasion, placental inflammation and pregnancy complications should... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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2 votes
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The Human Placenta Project

Cervical trophoblast: A proxy of placental health and function in early pregnancy trending idea

Sascha Drewlo kudos icon 1 Sascha Drewlo
There is a clear gap in our ability to investigate the placenta and pregnancy risk in the first trimester of pregnancy on a cellular level.

It is well established that protein expression is different in placental cells of pregnancies that developed placental disorders including severe preeclampsia (PE). This idea exploits the fact that the placenta naturally sheds hundreds of trophoblast cells into the cervical canal... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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3 votes
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The Human Placenta Project

MRI and US in the assessment of placental health and disease

deborah levine kudos icon 1 deborah levine
MR and ultrasound are listed in separate categories. However, US will always be a screening tool, used prior to MRI. When we are assessing diseases with plancetal etiologies, what is the best manner to integrate the information provided by both US and MRI. Can ultrasound be used to screen to lmiit the number of MR examinations? How is this affected by gestational age, position of the placenta with respect to maternal... more »

Which theme and set of objectives does your response address? THEME D: MRI

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The Human Placenta Project

Innovation in Regulatory Science trending idea

Anup Challa kudos icon + Anup Challa
Re. Aims G3 and G5

Contact: Anup Challa, Vanderbilt (anup.p.challa.1@vumc.org)

Assessment of the drug safety in pregnancy information necessary for new drug applications (NDAs) remains severely underpowered due to a lack of inclusion of pregnant patients in randomized, controlled drug trials (RCTs) for ethical reasons and the subsequent dearth of knowledge on the effects of many agents on the human maternal-fetal interface.... more »

Which theme and set of objectives does your response address? THEME G: Envisioning the Future

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4 votes
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The Human Placenta Project

Womb with a View

aagaardt kudos icon + aagaardt
This is such an exciting arena of work and advancement. While the arena of the "placental microbiome" has nearly garnished more editorials than original research, their continues to be more original and well controlled research demonstrating a low biomass, low abundance metagenomically identifiable community that is distinguishable from contaminant controls. Irrespective of which side of the "great sterility debate" it... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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4 votes
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The Human Placenta Project

Sexual dimorphism in placental physiology and pathophysiology

Arpita Mukhopadhyay kudos icon + Arpita Mukhopadhyay
The placenta is a unique organ, made up of cells with 2 similar yet distinct genetic makeup, maternal and fetal. Further, a placenta can be either a female or a male placenta, corresponding to the sex of the fetus. Understanding the role of sexual dimorphism of the placenta in terms of its development, maturation, function and basic physiology is needed but sorely lacking. Such insights will provide the grounding for... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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2 votes
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