It is well established that protein expression is different in placental cells of pregnancies that developed placental disorders including severe preeclampsia (PE). This idea exploits the fact that the placenta naturally sheds hundreds of trophoblast cells into the cervical canal... more »
The hypothesis is that a symbiotic relationship exists between the placenta and the fetal brain. A healthy placenta leads to healthy brain development in the fetus. Studies are warranted to find the correlation between the placenta and the fetal brain and the various clinical biomarkers and circulating factors aiding this process and the hypoxia-ischemia pathway
In humans, studies that consider the placenta as a mediator of the maternal environment (e.g., biomarkers, exercise) on pregnancy outcomes and in diverse populations are lacking.
Contact: Anup Challa, Vanderbilt (firstname.lastname@example.org)
Assessment of the drug safety in pregnancy information necessary for new drug applications (NDAs) remains severely underpowered due to a lack of inclusion of pregnant patients in randomized, controlled drug trials (RCTs) for ethical reasons and the subsequent dearth of knowledge on the effects of many agents on the human maternal-fetal interface.... more »
One could interrogate and compare the mutational signatures of both the fetal surface as well as the maternal surface of the placenta and to look for environmental carcinogenic footprints as well as endogenous oncogenic signatures such as APOBEC, etc…... more »