Showing 14 ideas for tag "thefuture"

The Human Placenta Project

Nothing makes sense except in the light of evolution trending idea

Like all biological structures, the placenta is the outcome of a historical evolutionary process. Thus, in order to understand the development, structure, and (dys)function of the placenta we must reconstruct the developmental evolutionary history of the maternal-fetal interface. The NICHD Human Placenta Project covers a wide breadth of research topics, but a noticeable gap is the lack of evolutionary studies that explicitly... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Barrier to clinical translation of novel ultrasound technologies

The field of ultrasound imaging has a robust technical research community that develops novel ultrasound technologies that could be applied to placental imaging. However, much of these technological developments never make it to clinical adoption because of a lack of collaboration involving the combination of industry, technical ultrasound researchers, and clinicians. Specifically, the latest clinical ultrasound systems... more »

Which theme and set of objectives does your response address? THEME E: Ultrasound

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The Human Placenta Project

Implantable placental biochemical sensors trending idea

The real-time biolochemical millieu of the devloping placenta is completely unknown. Sensors exist to sample microscopic changes in bioactive compounds in the atmosphere (for environmental health), and small biosensors have been developed to monitor hormonal and biochemical activity in tumors, for example. While not performed in every pregnancy, chorionic villus sampling is performed during pregnancy (removal of placental... more »

Which theme and set of objectives does your response address? THEME G: Envisioning the Future

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The Human Placenta Project

Cervical trophoblast: A proxy of placental health and function in early pregnancy trending idea

There is a clear gap in our ability to investigate the placenta and pregnancy risk in the first trimester of pregnancy on a cellular level.

It is well established that protein expression is different in placental cells of pregnancies that developed placental disorders including severe preeclampsia (PE). This idea exploits the fact that the placenta naturally sheds hundreds of trophoblast cells into the cervical canal... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Womb with a View

This is such an exciting arena of work and advancement. While the arena of the "placental microbiome" has nearly garnished more editorials than original research, their continues to be more original and well controlled research demonstrating a low biomass, low abundance metagenomically identifiable community that is distinguishable from contaminant controls. Irrespective of which side of the "great sterility debate" it... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Placental cell units and integrated funtions trending idea

Understanding the placenta from the cell unit constitution and the detailed cell diversity using new tools such as single cell approaches. The complexity of placental functions as a result of the integrated interaction between all trophoblasts subtypes, there is a big gap on the knowledge regarding the exact placental cellular diversity and individual functions (functional nodes). What we know so far and which are the... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Failed to die or failed to invade ?

Spiral artery remodeling is essential step of establishing uteroplacental circulation in human pregnancy. In early pregnancy, extravillous trophoblasts invade into maternal spiral artery, forming endovascular trophoblast plugs, and these endovascular trophoblasts undergo a phenotypic switch to express CD56, a NK cell marker. Little effort is made to understand what happen to these endovascular trophoblasts after initial... more »

Which theme and set of objectives does your response address? THEME B: Circulating Factors

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The Human Placenta Project

Correlation between Development of Placenta and the Fetal brain

The hypothesis is that a symbiotic relationship exists between the placenta and the fetal brain. A healthy placenta leads to healthy brain development in the fetus. Studies are warranted to find the correlation between the placenta and the fetal brain and the various clinical biomarkers and circulating factors aiding this process and the hypoxia-ischemia pathway

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Human placenta innate immunity

The human placenta is unique among mammals. We lack understanding of its immune complex and the innate responses that prevent or enable vertical transmission. The COVID pandemic highlights this gap. Where previous coronavirus outbreaks were associated with adverse pregnancy outcomes, SARS-Cov-2 does not appear to pass the placenta and negatively impact fetal development. Interestingly, several groups have highlight SARS-Cov-2... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Simultaneous maternal and fetal blood flow assessment in the placenta using umbilical vein Doppler

A big issue in assessment of placental abnormalities in vivo is that the placenta has two separate blood supplies, maternal and fetal. Presently, there are no easy ways to directly assess these contributing flows at the same time. If there were such a method, it could greatly enhance placental evaluation in a myriad of ways. For instance, it would be possible to show the effects of various therapies on both the maternal... more »

Which theme and set of objectives does your response address? THEME E: Ultrasound

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The Human Placenta Project

Innovation in Regulatory Science trending idea

Re. Aims G3 and G5

Contact: Anup Challa, Vanderbilt (anup.p.challa.1@vumc.org)

Assessment of the drug safety in pregnancy information necessary for new drug applications (NDAs) remains severely underpowered due to a lack of inclusion of pregnant patients in randomized, controlled drug trials (RCTs) for ethical reasons and the subsequent dearth of knowledge on the effects of many agents on the human maternal-fetal interface.... more »

Which theme and set of objectives does your response address? THEME G: Envisioning the Future

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The Human Placenta Project

Placental Mutational Signature and Cancer

It would be interesting to investigate whether the mutational signature of the fetal placental surface may correlate with susceptibility to develop cancer across lifetime.

One could interrogate and compare the mutational signatures of both the fetal surface as well as the maternal surface of the placenta and to look for environmental carcinogenic footprints as well as endogenous oncogenic signatures such as APOBEC, etc…... more »

Which theme and set of objectives does your response address? GENERAL FEEDBACK: New Research Theme or Objective

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The Human Placenta Project

Placental Inflammation trending idea

Placental inflammation is a key driver of adverse pregnancy events and also directly impacts fetal and neonatal development. A key focus on how inflammatory cells orchestrate immune tolerance and immunity to infection in healthy human placentas as well as how events including infection and allogeneic inflammatory responses contribute to failed trophoblast invasion, placental inflammation and pregnancy complications should... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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