Showing 4 ideas for tag "OtherIdeas"

The Human Placenta Project

Nothing makes sense except in the light of evolution trending idea

Like all biological structures, the placenta is the outcome of a historical evolutionary process. Thus, in order to understand the development, structure, and (dys)function of the placenta we must reconstruct the developmental evolutionary history of the maternal-fetal interface. The NICHD Human Placenta Project covers a wide breadth of research topics, but a noticeable gap is the lack of evolutionary studies that explicitly... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Failed to die or failed to invade ?

Spiral artery remodeling is essential step of establishing uteroplacental circulation in human pregnancy. In early pregnancy, extravillous trophoblasts invade into maternal spiral artery, forming endovascular trophoblast plugs, and these endovascular trophoblasts undergo a phenotypic switch to express CD56, a NK cell marker. Little effort is made to understand what happen to these endovascular trophoblasts after initial... more »

Which theme and set of objectives does your response address? THEME B: Circulating Factors

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3 votes
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The Human Placenta Project

Innovation in Regulatory Science trending idea

Re. Aims G3 and G5

Contact: Anup Challa, Vanderbilt (anup.p.challa.1@vumc.org)

Assessment of the drug safety in pregnancy information necessary for new drug applications (NDAs) remains severely underpowered due to a lack of inclusion of pregnant patients in randomized, controlled drug trials (RCTs) for ethical reasons and the subsequent dearth of knowledge on the effects of many agents on the human maternal-fetal interface.... more »

Which theme and set of objectives does your response address? THEME G: Envisioning the Future

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The Human Placenta Project

Placental Inflammation trending idea

Placental inflammation is a key driver of adverse pregnancy events and also directly impacts fetal and neonatal development. A key focus on how inflammatory cells orchestrate immune tolerance and immunity to infection in healthy human placentas as well as how events including infection and allogeneic inflammatory responses contribute to failed trophoblast invasion, placental inflammation and pregnancy complications should... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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2 votes
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