Showing 2 ideas for tag "therapies"

The Human Placenta Project

Optimising testing of new therapeutics to ensure an effective pathway to translation.

Currently, not enough time or funding is invested in the pre-clinical and early phase clinical testing of new therapies to treat pregnancy complications. At present, we often jump from animal models to clinical trials using a single dose of the therapy, and test it in women with a "broad" and/or severe phenotype of disease. We do this without gathering pharmacokinetic/pharmacodynamic/dosing information from these women,... more »

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The Human Placenta Project

Immunological responses to nanomedicines in pregnant women

There is growing interest in using nanomedicines to treat pregnancy complications, with several different therapies showing success in pre-clinical models. However, we must remember that to date, all of the published safety data on different types of nanoparticles has been obtained from studies in non pregnant animals and humans. Given the significant changes in immune function noted in pregnancy, it is critical to determine... more »

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