Showing 29 ideas for tag "TheFuture"

The Human Placenta Project

Barrier to clinical translation of novel ultrasound technologies

The field of ultrasound imaging has a robust technical research community that develops novel ultrasound technologies that could be applied to placental imaging. However, much of these technological developments never make it to clinical adoption because of a lack of collaboration involving the combination of industry, technical ultrasound researchers, and clinicians. Specifically, the latest clinical ultrasound systems... more »

Voting

2 votes
Ideate

The Human Placenta Project

Cervical trophoblast: A proxy of placental health and function in early pregnancy

There is a clear gap in our ability to investigate the placenta and pregnancy risk in the first trimester of pregnancy on a cellular level.

It is well established that protein expression is different in placental cells of pregnancies that developed placental disorders including severe preeclampsia (PE). This idea exploits the fact that the placenta naturally sheds hundreds of trophoblast cells into the cervical canal... more »

Voting

4 votes
Ideate

The Human Placenta Project

Nothing makes sense except in the light of evolution

Like all biological structures, the placenta is the outcome of a historical evolutionary process. Thus, in order to understand the development, structure, and (dys)function of the placenta we must reconstruct the developmental evolutionary history of the maternal-fetal interface. The NICHD Human Placenta Project covers a wide breadth of research topics, but a noticeable gap is the lack of evolutionary studies that explicitly... more »

Voting

5 votes
Ideate

The Human Placenta Project

MRI - Premeeting Discussion Summary

MRI Safety in First Trimester

Is there a need for a consensus statement from experts representing major societies such as ISMRM, RSNA, SPR, Obstetrics and Gynecology (e.g. Society of Maternal-Fetal Medicine, ISUOG), about the safety of fetal MRI, particularly in the first trimester for research purposes as no specific FDA guidelines exist?

Some sites using as early as 12 weeks.

Do we need more nonhuman primate studies?... more »

Voting

1 vote
Ideate

The Human Placenta Project

Implantable placental biochemical sensors

The real-time biolochemical millieu of the devloping placenta is completely unknown. Sensors exist to sample microscopic changes in bioactive compounds in the atmosphere (for environmental health), and small biosensors have been developed to monitor hormonal and biochemical activity in tumors, for example. While not performed in every pregnancy, chorionic villus sampling is performed during pregnancy (removal of placental... more »

Voting

6 votes
Ideate

The Human Placenta Project

Placental cell units and integrated funtions

Understanding the placenta from the cell unit constitution and the detailed cell diversity using new tools such as single cell approaches. The complexity of placental functions as a result of the integrated interaction between all trophoblasts subtypes, there is a big gap on the knowledge regarding the exact placental cellular diversity and individual functions (functional nodes). What we know so far and which are the... more »

Voting

4 votes
Ideate

The Human Placenta Project

Womb with a View

This is such an exciting arena of work and advancement. While the arena of the "placental microbiome" has nearly garnished more editorials than original research, their continues to be more original and well controlled research demonstrating a low biomass, low abundance metagenomically identifiable community that is distinguishable from contaminant controls. Irrespective of which side of the "great sterility debate" it... more »

Voting

4 votes
Ideate

The Human Placenta Project

Correlation between Development of Placenta and the Fetal brain

The hypothesis is that a symbiotic relationship exists between the placenta and the fetal brain. A healthy placenta leads to healthy brain development in the fetus. Studies are warranted to find the correlation between the placenta and the fetal brain and the various clinical biomarkers and circulating factors aiding this process and the hypoxia-ischemia pathway

Voting

6 votes
Ideate

The Human Placenta Project

Standardization of tissue processing and storage in repositories, and collection and sharing of data

A recurring theme throughout the pre-meeting reports is the need to establish standards for generation of repositories of well phenotyped placental tissue samples with collection and storage in a manner that allows comparable analysis utilizing contemporary techniques across different laboratories. Additionally the need for collection of biospecimens across the entirety of normal gestation with collection of appropriate... more »

Voting

5 votes
Ideate

The Human Placenta Project

Placental Inflammation

Placental inflammation is a key driver of adverse pregnancy events and also directly impacts fetal and neonatal development. A key focus on how inflammatory cells orchestrate immune tolerance and immunity to infection in healthy human placentas as well as how events including infection and allogeneic inflammatory responses contribute to failed trophoblast invasion, placental inflammation and pregnancy complications should... more »

Voting

6 votes
Ideate

The Human Placenta Project

Failed to die or failed to invade ?

Spiral artery remodeling is essential step of establishing uteroplacental circulation in human pregnancy. In early pregnancy, extravillous trophoblasts invade into maternal spiral artery, forming endovascular trophoblast plugs, and these endovascular trophoblasts undergo a phenotypic switch to express CD56, a NK cell marker. Little effort is made to understand what happen to these endovascular trophoblasts after initial... more »

Voting

4 votes
Ideate

The Human Placenta Project

Human placenta innate immunity

The human placenta is unique among mammals. We lack understanding of its immune complex and the innate responses that prevent or enable vertical transmission. The COVID pandemic highlights this gap. Where previous coronavirus outbreaks were associated with adverse pregnancy outcomes, SARS-Cov-2 does not appear to pass the placenta and negatively impact fetal development. Interestingly, several groups have highlight SARS-Cov-2... more »

Voting

4 votes
Ideate

The Human Placenta Project

Envisioning the Future: Premeeting Discussion Summary

It is easy for a crystal ball to predict that the future will include enhanced technology, i.e. digital medicine, higher resolution ultrasound, etc; novel biomarkers, including both genomic and proteomic markers, that can be used to predict disease risk or evaluate disease status; and expansive data repositories containing patient data, physician notes and patient reported outcomes and the lifetime histories of the mother... more »

Voting

4 votes
Ideate

The Human Placenta Project

Simultaneous maternal and fetal blood flow assessment in the placenta using umbilical vein Doppler

A big issue in assessment of placental abnormalities in vivo is that the placenta has two separate blood supplies, maternal and fetal. Presently, there are no easy ways to directly assess these contributing flows at the same time. If there were such a method, it could greatly enhance placental evaluation in a myriad of ways. For instance, it would be possible to show the effects of various therapies on both the maternal... more »

Voting

5 votes
Ideate