In humans, studies that consider the placenta as a mediator of the maternal environment (e.g., biomarkers, exercise) on pregnancy outcomes and in diverse populations are lacking.
It is well established that protein expression is different in placental cells of pregnancies that developed placental disorders including severe preeclampsia (PE). This idea exploits the fact that the placenta naturally sheds hundreds of trophoblast cells into the cervical canal... more »
Is there a need for a consensus statement from experts representing major societies such as ISMRM, RSNA, SPR, Obstetrics and Gynecology (e.g. Society of Maternal-Fetal Medicine, ISUOG), about the safety of fetal MRI, particularly in the first trimester for research purposes as no specific FDA guidelines exist?
Some sites using as early as 12 weeks.
Do we need more nonhuman primate studies?... more »
The hypothesis is that a symbiotic relationship exists between the placenta and the fetal brain. A healthy placenta leads to healthy brain development in the fetus. Studies are warranted to find the correlation between the placenta and the fetal brain and the various clinical biomarkers and circulating factors aiding this process and the hypoxia-ischemia pathway