Showing 6 ideas for tag "GenomicEpiGenomic"

The Human Placenta Project

Basic Research Premeeting Discussion Summary - L Myatt & Y Sadovsky

Key Achievements/Breakthroughs

• Development of trophoblast and decidual organoids

• Induced pluripotent stem cells

• Introduction of single cell and spatial technology to probe placental biology

• Appreciation of the roles of extracellular vesicles and the development of tools to probe their mechanism of action and function

• Advances in "omics" technologies and integration of "omic" data

• Emergence of microfluidic... more »

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The Human Placenta Project

CRISPR Epigenetic Control of Gene Expression

Was alerted to a CRISPR approach that allows epigenetic regulation of gene expression. This might prove extremely useful for exploring the maternal/fetal/placental ecosystem in animal models.

https://www.ucsf.edu/news/2021/04/420306/new-crispr-technology-offers-unrivaled-control-epigenetic-inheritance

and https://www.cell.com/cell/fulltext/S0092-8674(21)00353-6

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The Human Placenta Project

Genetic variants and placental function

Our research group in the NIDDK Intramural Research Program has investigated the risk of APOL1 genetic variants in many types of kidney diseases, including focal segmental nephrosclerosis, HIV-associated nephropathy, and hypertension-attributed kidney disease. Together, these disease account for much of the excess chronic kidney disease risk among African-Americans.

We are accumulating evidence that APOL1 risk variants... more »

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The Human Placenta Project

Placental Mutational Signature and Cancer

It would be interesting to investigate whether the mutational signature of the fetal placental surface may correlate with susceptibility to develop cancer across lifetime.

One could interrogate and compare the mutational signatures of both the fetal surface as well as the maternal surface of the placenta and to look for environmental carcinogenic footprints as well as endogenous oncogenic signatures such as APOBEC, etc…... more »

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The Human Placenta Project

Integrated study of placenta and pregnancy, towards personalized medicine

Unlike any other pathologies, adverse pregnancy can be captured from its inception to its conclusion as these are well-defined start and endpoints. Additionally, pregnancy occurs in a defined time frame lasting less than a year (<42 weeks). Nearly all other pathologies develop over years or decades. Relative to other extensive population studies like the Framingham heart study following pregnancy from conception to delivery... more »

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