Showing 39 ideas for tag "basicresearch"

The Human Placenta Project

Multi-component systems to model the Placenta ecosystem

The maternal/fetal/placenta ecosystem is complex, with dynamic communication happening among all of the components. Leveraging tissue on a chip technologies one can envision studying interactions of decidua, maternal blood component, immune cells, placenta, etc. to systematically interrogate key interactions. I wonder whether the community feels this is feasible, and also whether iPSC blastoids would be useful in such... more »

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The Human Placenta Project

Potential involvement of trophoblast inclusions in the etiology of Autism Spectrum Disorders

One such topic concerns the etiology of autism and autism spectrum disorders, for which the placenta may be involved. Recent research has identified an increased incidence of trophoblast inclusions in the placenta of children that have developed ASD. This lesion also may be associated with, or indicative of altered zinc nutriture, as zinc deficiencies also have been observed in children that develop ASD

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The Human Placenta Project

The Placenta and Baby Brain

Submitted on behalf of a colleague at NINDS

Despite the central role of the placenta in fetal development, and despite the splendid work of the HPP, only limited information is available about characteristics of the placenta that are systematically related to health or disease, and especially critically to neurologic outcome, in the newborn child. This major information gap is worse for infants born at or near term,... more »

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The Human Placenta Project

Basic Research Premeeting Discussion Summary - L Myatt & Y Sadovsky

Key Achievements/Breakthroughs

• Development of trophoblast and decidual organoids

• Induced pluripotent stem cells

• Introduction of single cell and spatial technology to probe placental biology

• Appreciation of the roles of extracellular vesicles and the development of tools to probe their mechanism of action and function

• Advances in "omics" technologies and integration of "omic" data

• Emergence of microfluidic... more »

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The Human Placenta Project

Cervical trophoblast: A proxy of placental health and function in early pregnancy

There is a clear gap in our ability to investigate the placenta and pregnancy risk in the first trimester of pregnancy on a cellular level.

It is well established that protein expression is different in placental cells of pregnancies that developed placental disorders including severe preeclampsia (PE). This idea exploits the fact that the placenta naturally sheds hundreds of trophoblast cells into the cervical canal... more »

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The Human Placenta Project

Nothing makes sense except in the light of evolution

Like all biological structures, the placenta is the outcome of a historical evolutionary process. Thus, in order to understand the development, structure, and (dys)function of the placenta we must reconstruct the developmental evolutionary history of the maternal-fetal interface. The NICHD Human Placenta Project covers a wide breadth of research topics, but a noticeable gap is the lack of evolutionary studies that explicitly... more »

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The Human Placenta Project

Developmental Impact of the Placenta

A stated on other areas of the forum, though the placenta plays a central role in fetal development, there are still large gaps in knowledge on how altered placental function can directly impact key fetal organ development, particularly for the brain, pulmonary and cardiovascular systems. Supporting the ongoing creation of in vitro models coupling key components of the human placental ecosystem (i.e. primary decidual... more »

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The Human Placenta Project

consider additional study of placental transport?

I'm not a placental researcher - I work in the Intellectual and Developmental Disabilities Branch (IDDB) at NICHD. But several conditions of interest to our branch involve transport (or lack thereof) of nutrients, toxins, or other factors across the placenta (alcohol, lead, oxygen, and many others). Greater understanding of factors that predict placental transport of such agents would be very informative to the IDD research... more »

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The Human Placenta Project

Implantable placental biochemical sensors

The real-time biolochemical millieu of the devloping placenta is completely unknown. Sensors exist to sample microscopic changes in bioactive compounds in the atmosphere (for environmental health), and small biosensors have been developed to monitor hormonal and biochemical activity in tumors, for example. While not performed in every pregnancy, chorionic villus sampling is performed during pregnancy (removal of placental... more »

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The Human Placenta Project

MRI and US in the assessment of placental health and disease

MR and ultrasound are listed in separate categories. However, US will always be a screening tool, used prior to MRI. When we are assessing diseases with plancetal etiologies, what is the best manner to integrate the information provided by both US and MRI. Can ultrasound be used to screen to lmiit the number of MR examinations? How is this affected by gestational age, position of the placenta with respect to maternal... more »

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The Human Placenta Project

Correlation between Development of Placenta and the Fetal brain

The hypothesis is that a symbiotic relationship exists between the placenta and the fetal brain. A healthy placenta leads to healthy brain development in the fetus. Studies are warranted to find the correlation between the placenta and the fetal brain and the various clinical biomarkers and circulating factors aiding this process and the hypoxia-ischemia pathway

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The Human Placenta Project

Standardization of tissue processing and storage in repositories, and collection and sharing of data

A recurring theme throughout the pre-meeting reports is the need to establish standards for generation of repositories of well phenotyped placental tissue samples with collection and storage in a manner that allows comparable analysis utilizing contemporary techniques across different laboratories. Additionally the need for collection of biospecimens across the entirety of normal gestation with collection of appropriate... more »

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The Human Placenta Project

Placental cell units and integrated funtions

Understanding the placenta from the cell unit constitution and the detailed cell diversity using new tools such as single cell approaches. The complexity of placental functions as a result of the integrated interaction between all trophoblasts subtypes, there is a big gap on the knowledge regarding the exact placental cellular diversity and individual functions (functional nodes). What we know so far and which are the... more »

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