Showing 15 ideas for tag "DOHaD"

The Human Placenta Project

The Placenta and Baby Brain

Submitted on behalf of a colleague at NINDS

Despite the central role of the placenta in fetal development, and despite the splendid work of the HPP, only limited information is available about characteristics of the placenta that are systematically related to health or disease, and especially critically to neurologic outcome, in the newborn child. This major information gap is worse for infants born at or near term,... more »

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The Human Placenta Project

Developmental Impact of the Placenta

A stated on other areas of the forum, though the placenta plays a central role in fetal development, there are still large gaps in knowledge on how altered placental function can directly impact key fetal organ development, particularly for the brain, pulmonary and cardiovascular systems. Supporting the ongoing creation of in vitro models coupling key components of the human placental ecosystem (i.e. primary decidual... more »

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The Human Placenta Project

consider additional study of placental transport?

I'm not a placental researcher - I work in the Intellectual and Developmental Disabilities Branch (IDDB) at NICHD. But several conditions of interest to our branch involve transport (or lack thereof) of nutrients, toxins, or other factors across the placenta (alcohol, lead, oxygen, and many others). Greater understanding of factors that predict placental transport of such agents would be very informative to the IDD research... more »

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The Human Placenta Project

Correlation between Development of Placenta and the Fetal brain

The hypothesis is that a symbiotic relationship exists between the placenta and the fetal brain. A healthy placenta leads to healthy brain development in the fetus. Studies are warranted to find the correlation between the placenta and the fetal brain and the various clinical biomarkers and circulating factors aiding this process and the hypoxia-ischemia pathway

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The Human Placenta Project

Placenta as environmental protector

The placenta is a critical barrier and protector of the developing fetus from environmental insult. Growing data suggests that the chemical assault on the human placenta is larger than we ever appreciated and rapidly expanding. Understanding how the placenta both protects and is sex-specifically affected by the chemical contaminants every human body now contains is vital for understanding fetal health and the health of... more »

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The Human Placenta Project

Characterization of the placental epi/genome in population studies

There is a need for in-depth characterization of placental epi/genetic profiles from normal and pathologic pregnancies from population studies with standardized data and sample collection methods. Importantly, an effort should be made to include samples from diverse and understudied populations. Knowledge of normal and pathology-linked epi/genetic changes in the placenta will expand our biologic understanding, and importantly... more »

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The Human Placenta Project

characterizing genomic networks of human term placenta in both bulk tissue and cellular resolution

Currently, molecular data (transcriptome, methylome, etc) are lacking for NORMAL (non-pathological) TERM human placentae. Existing public databases usually lack placental data. Although some placental single cell data are available, they are usually derived from early pregnancies or diseased placentae. There is an urgent need to perform thorough molecular characterization of human term placenta from population studies.... more »

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The Human Placenta Project

feedback from an placental epidemiologist

I participated in the HPP in the beginning, went to a meeting, and submitted a funding proposal. I have lost touch since. I don't know all that has been achieved, or how the program has evolved. My impression in the beginning was that there was a strong emphasis on obstetric outcomes and technologies that could produce, for the benefit of the physician, rapid and clinically meaningful results. Innovation in technology... more »

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The Human Placenta Project

Single cell and placental research

I am the Principal Investigator of new birth cohort study that is currently being planned and will be implemented in Nigeria. We plan to collect biological samples including placental tissue. We will appreciate insight from investigators in the field about how single cell research will advance scientific investigation of the placenta within the context of developmental origin of health and diseases. This will enable know... more »

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The Human Placenta Project

Placental Mutational Signature and Cancer

It would be interesting to investigate whether the mutational signature of the fetal placental surface may correlate with susceptibility to develop cancer across lifetime.

One could interrogate and compare the mutational signatures of both the fetal surface as well as the maternal surface of the placenta and to look for environmental carcinogenic footprints as well as endogenous oncogenic signatures such as APOBEC, etc…... more »

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The Human Placenta Project

Human Umbilical Cord Development

Very little is known about development of the human umbilical cord and insertion into the fetal abdominal wall, yet developmental abnormalities contribute to multiple recurring embryonic malformations, including limb-body wall complex, pentalogy of Cantrell and OEIS (omphalocele, exstrophy of bladder or cloaca, imperforate anus, and spinal defects). In addition, anomalies are more frequently associated with a two vessel... more »

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The Human Placenta Project

Environmental Exposures

Environmental exposures (physical, chemical and built environment) are associated with adverse pregnancy outcomes, and depending on timing of exposure relative to sensitive developmental windows, can be linked to early childhood and lifelong adverse health consequences for the child. Environmental exposures are also strongly associated with maternal health during pregnancy and the postpartum period. Air pollution especially... more »

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The Human Placenta Project

Applying a Systems-based Approach

We have begun to apply systems biology to identify potential biomarkers to enhance our understanding of the biology of placental development and improve the care of mother and developing fetus. Pregnancy, however, is like the 3-body challenge in physics as it intimately involves both the individual and interactive development of the pregnant mother, the fetus and the placenta. These interactions and their potential impact... more »

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The Human Placenta Project

Big Data, AI/ML: Treasure Chest of Pandora's box?

Women's health and obstetrics in general, and the placenta, in particular, have not received the same level of research focus as many specific disease areas in spite of impacting much greater numbers of people because of appropriate limitation in experimental approaches. The measurement and aggregation of significant data over the course of a pregnancy (and post-partum) involving clinical and physiological biomarkers... more »

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