One such topic concerns the etiology of autism and autism spectrum disorders, for which the placenta may be involved. Recent research has identified an increased incidence of trophoblast inclusions in the placenta of children that have developed ASD. This lesion also may be associated with, or indicative of altered zinc nutriture, as zinc deficiencies also have been observed in children that develop ASD
It is well established that protein expression is different in placental cells of pregnancies that developed placental disorders including severe preeclampsia (PE). This idea exploits the fact that the placenta naturally sheds hundreds of trophoblast cells into the cervical canal... more »
The hypothesis is that a symbiotic relationship exists between the placenta and the fetal brain. A healthy placenta leads to healthy brain development in the fetus. Studies are warranted to find the correlation between the placenta and the fetal brain and the various clinical biomarkers and circulating factors aiding this process and the hypoxia-ischemia pathway
Is there a need for a consensus statement from experts representing major societies such as ISMRM, RSNA, SPR, Obstetrics and Gynecology (e.g. Society of Maternal-Fetal Medicine, ISUOG), about the safety of fetal MRI, particularly in the first trimester for research purposes as no specific FDA guidelines exist?
Some sites using as early as 12 weeks.
Do we need more nonhuman primate studies?... more »
Contact: Anup Challa, Vanderbilt (firstname.lastname@example.org)
Assessment of the drug safety in pregnancy information necessary for new drug applications (NDAs) remains severely underpowered due to a lack of inclusion of pregnant patients in randomized, controlled drug trials (RCTs) for ethical reasons and the subsequent dearth of knowledge on the effects of many agents on the human maternal-fetal interface.... more »
• Ensure that people with disabilities (PWD) are included among the subject populations – and special efforts are made to support their reproductive health and opportunities. Often, PWD are not asked about reproductive health and are not offered... more »
• BEGIN in this space, VALUE diverse populations and put them at the center of your efforts
o remember racial/ethnic cultural diversity is not always present in biobanks
• This takes real TIME, needs to be a concerted and consistent effort in relationship building, trust-building.
• Will need to build TRUST- this may include community leaders such as local church/faith... more »
Medwire News (4/20, McDermid) reports, "Visceral adipose tissue depth...measured during the first trimester of pregnancy predicts gestational diabetes better than current clinical indicators," investigators concluded. What's more, "the technique had a positive... more »
The proper identification and clinical management of preeclampsia have been my passion since becoming an ob-gyn physician in 1987. The disproportionate deaths of pregnant women and new moms, especially women of color are unsettling. Early angiogenic markers that help identify increased risk factors for the diagnosis of preeclampsia would be monumental.