In humans, studies that consider the placenta as a mediator of the maternal environment (e.g., biomarkers, exercise) on pregnancy outcomes and in diverse populations are lacking.
One such topic concerns the etiology of autism and autism spectrum disorders, for which the placenta may be involved. Recent research has identified an increased incidence of trophoblast inclusions in the placenta of children that have developed ASD. This lesion also may be associated with, or indicative of altered zinc nutriture, as zinc deficiencies also have been observed in children that develop ASD
Description and potential roles of placental extracellular vesicles (EVs)
Circulating RNAs, placental microRNAs
Advances in genomics, sequencing technologies & cfDNA field
Bioinformatics advances integrating information across different omics datasets
Recognition of placental sexual dimorphism
Discovery of placental cells shedding into the cervix
Recognition of protein misfolding... more »
The hypothesis is that a symbiotic relationship exists between the placenta and the fetal brain. A healthy placenta leads to healthy brain development in the fetus. Studies are warranted to find the correlation between the placenta and the fetal brain and the various clinical biomarkers and circulating factors aiding this process and the hypoxia-ischemia pathway
Understanding the influence of the placenta and placenta-derived circulating factors on maternal health, including its impact on infectious disease.
Patients have helped us to design our observational cohort study of early onset fetal growth restriction. They told us how they would like to be recruited to such a study and what they thought of being recruited. Was it a burden to take part in a research study when their baby is extremely small and has a high chance of dying?... more »
There were premeeting planning discussions across all 7 themes. As the moderators upload summaries we are pinning them to the Welcome page (click "Welcome" at top). You can scroll down to the bottom to see them. We would love questions and comments/suggestions. This is intended to be transparent and inclusive.