Showing 7 ideas for tag "ClinicalBiomarkers"

The Human Placenta Project

Cervical trophoblast: A proxy of placental health and function in early pregnancy trending idea

There is a clear gap in our ability to investigate the placenta and pregnancy risk in the first trimester of pregnancy on a cellular level.

It is well established that protein expression is different in placental cells of pregnancies that developed placental disorders including severe preeclampsia (PE). This idea exploits the fact that the placenta naturally sheds hundreds of trophoblast cells into the cervical canal... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Need for a strategic approach to clinical biomarker discovery trending idea

The drug development world has evolved a set of generally agreed upon steps for advancing potential targets forward. This is in part because the end goal - FDA approval and commercial viability drive the requirements and processes. The identification of clinically useful biomarkers is often an outcome of basic research into a biologic process that tangentially is recognized to have clinical utility. Validation processes... more »

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The Human Placenta Project

Correlation between Development of Placenta and the Fetal brain

The hypothesis is that a symbiotic relationship exists between the placenta and the fetal brain. A healthy placenta leads to healthy brain development in the fetus. Studies are warranted to find the correlation between the placenta and the fetal brain and the various clinical biomarkers and circulating factors aiding this process and the hypoxia-ischemia pathway

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Supporting People with Disabilities trending idea

The National Center for Medical Rehabilitation Research (located within the NICHD) would like to highlight three issues that may arise in the context of the Human Placenta Project:

ā€¢ Ensure that people with disabilities (PWD) are included among the subject populations ā€“ and special efforts are made to support their reproductive health and opportunities. Often, PWD are not asked about reproductive health and are not offered... more »

Which theme and set of objectives does your response address? THEME F: Planning Translation ā€“ Hearing all Voices

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The Human Placenta Project

Innovation in Regulatory Science trending idea

Re. Aims G3 and G5

Contact: Anup Challa, Vanderbilt (anup.p.challa.1@vumc.org)

Assessment of the drug safety in pregnancy information necessary for new drug applications (NDAs) remains severely underpowered due to a lack of inclusion of pregnant patients in randomized, controlled drug trials (RCTs) for ethical reasons and the subsequent dearth of knowledge on the effects of many agents on the human maternal-fetal interface.... more »

Which theme and set of objectives does your response address? THEME G: Envisioning the Future

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The Human Placenta Project

Potential involvement of trophoblast inclusions in the etiology of Autism Spectrum Disorders

One such topic concerns the etiology of autism and autism spectrum disorders, for which the placenta may be involved. Recent research has identified an increased incidence of trophoblast inclusions in the placenta of children that have developed ASD. This lesion also may be associated with, or indicative of altered zinc nutriture, as zinc deficiencies also have been observed in children that develop ASD

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Sexual dimorphism in placental physiology and pathophysiology

The placenta is a unique organ, made up of cells with 2 similar yet distinct genetic makeup, maternal and fetal. Further, a placenta can be either a female or a male placenta, corresponding to the sex of the fetus. Understanding the role of sexual dimorphism of the placenta in terms of its development, maturation, function and basic physiology is needed but sorely lacking. Such insights will provide the grounding for... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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