Showing 39 ideas for tag "BasicResearch"

The Human Placenta Project

Womb with a View

This is such an exciting arena of work and advancement. While the arena of the "placental microbiome" has nearly garnished more editorials than original research, their continues to be more original and well controlled research demonstrating a low biomass, low abundance metagenomically identifiable community that is distinguishable from contaminant controls. Irrespective of which side of the "great sterility debate" it... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Sexual dimorphism in placental physiology and pathophysiology

The placenta is a unique organ, made up of cells with 2 similar yet distinct genetic makeup, maternal and fetal. Further, a placenta can be either a female or a male placenta, corresponding to the sex of the fetus. Understanding the role of sexual dimorphism of the placenta in terms of its development, maturation, function and basic physiology is needed but sorely lacking. Such insights will provide the grounding for... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Failed to die or failed to invade ?

Spiral artery remodeling is essential step of establishing uteroplacental circulation in human pregnancy. In early pregnancy, extravillous trophoblasts invade into maternal spiral artery, forming endovascular trophoblast plugs, and these endovascular trophoblasts undergo a phenotypic switch to express CD56, a NK cell marker. Little effort is made to understand what happen to these endovascular trophoblasts after initial... more »

Which theme and set of objectives does your response address? THEME B: Circulating Factors

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The Human Placenta Project

Human placenta innate immunity

The human placenta is unique among mammals. We lack understanding of its immune complex and the innate responses that prevent or enable vertical transmission. The COVID pandemic highlights this gap. Where previous coronavirus outbreaks were associated with adverse pregnancy outcomes, SARS-Cov-2 does not appear to pass the placenta and negatively impact fetal development. Interestingly, several groups have highlight SARS-Cov-2... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Envisioning the Future: Premeeting Discussion Summary trending idea

It is easy for a crystal ball to predict that the future will include enhanced technology, i.e. digital medicine, higher resolution ultrasound, etc; novel biomarkers, including both genomic and proteomic markers, that can be used to predict disease risk or evaluate disease status; and expansive data repositories containing patient data, physician notes and patient reported outcomes and the lifetime histories of the mother... more »

Which theme and set of objectives does your response address? THEME G: Envisioning the Future

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The Human Placenta Project

CRISPR Epigenetic Control of Gene Expression

Was alerted to a CRISPR approach that allows epigenetic regulation of gene expression. This might prove extremely useful for exploring the maternal/fetal/placental ecosystem in animal models.

https://www.ucsf.edu/news/2021/04/420306/new-crispr-technology-offers-unrivaled-control-epigenetic-inheritance

and https://www.cell.com/cell/fulltext/S0092-8674(21)00353-6

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

characterizing genomic networks of human term placenta in both bulk tissue and cellular resolution

Currently, molecular data (transcriptome, methylome, etc) are lacking for NORMAL (non-pathological) TERM human placentae. Existing public databases usually lack placental data. Although some placental single cell data are available, they are usually derived from early pregnancies or diseased placentae. There is an urgent need to perform thorough molecular characterization of human term placenta from population studies.... more »

Which theme and set of objectives does your response address? GENERAL FEEDBACK: New Research Theme or Objective

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The Human Placenta Project

Simultaneous maternal and fetal blood flow assessment in the placenta using umbilical vein Doppler trending idea

A big issue in assessment of placental abnormalities in vivo is that the placenta has two separate blood supplies, maternal and fetal. Presently, there are no easy ways to directly assess these contributing flows at the same time. If there were such a method, it could greatly enhance placental evaluation in a myriad of ways. For instance, it would be possible to show the effects of various therapies on both the maternal... more »

Which theme and set of objectives does your response address? THEME E: Ultrasound

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The Human Placenta Project

Genetic variants and placental function

Our research group in the NIDDK Intramural Research Program has investigated the risk of APOL1 genetic variants in many types of kidney diseases, including focal segmental nephrosclerosis, HIV-associated nephropathy, and hypertension-attributed kidney disease. Together, these disease account for much of the excess chronic kidney disease risk among African-Americans.

We are accumulating evidence that APOL1 risk variants... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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The Human Placenta Project

Single cell and placental research

I am the Principal Investigator of new birth cohort study that is currently being planned and will be implemented in Nigeria. We plan to collect biological samples including placental tissue. We will appreciate insight from investigators in the field about how single cell research will advance scientific investigation of the placenta within the context of developmental origin of health and diseases. This will enable know... more »

Which theme and set of objectives does your response address? GENERAL FEEDBACK: New Research Theme or Objective

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The Human Placenta Project

Supporting People with Disabilities

The National Center for Medical Rehabilitation Research (located within the NICHD) would like to highlight three issues that may arise in the context of the Human Placenta Project:

• Ensure that people with disabilities (PWD) are included among the subject populations – and special efforts are made to support their reproductive health and opportunities. Often, PWD are not asked about reproductive health and are not offered... more »

Which theme and set of objectives does your response address? THEME F: Planning Translation – Hearing all Voices

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The Human Placenta Project

Hearing all voices - Premeeting Discussion Summary - Tracy Bale and Ann Celi

Community Engagement Challenges and Opportunities

• BEGIN in this space, VALUE diverse populations and put them at the center of your efforts

o remember racial/ethnic cultural diversity is not always present in biobanks

• This takes real TIME, needs to be a concerted and consistent effort in relationship building, trust-building.

• Will need to build TRUST- this may include community leaders such as local church/faith... more »

Which theme and set of objectives does your response address? THEME F: Planning Translation – Hearing all Voices

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The Human Placenta Project

Human Umbilical Cord Development

Very little is known about development of the human umbilical cord and insertion into the fetal abdominal wall, yet developmental abnormalities contribute to multiple recurring embryonic malformations, including limb-body wall complex, pentalogy of Cantrell and OEIS (omphalocele, exstrophy of bladder or cloaca, imperforate anus, and spinal defects). In addition, anomalies are more frequently associated with a two vessel... more »

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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