Advancing Bioprinting and Regenerative Medicine Solutions for Obstetric, Gynecologic, and Pediatric Applications

Tissue engineering in utero trending idea

Description :

Tissue engineering in utero- the fetal environment offers a unique environment which is uniquely suit for tissue regeneration. Recent advances in fetal surgery, prenatal imaging, and minimally invasive techniques now make the fetal environment more accessible. Using tissue engineered constructs to repair of replace tissues that are diseased, damaged , or congenitally absent, one can not only take advantage of the unique properties of fetal wound healing to repair a congenital anomaly but also leverage fetal environment to restore normal development.

1. Where are we? What do you consider as the major accomplishment(s) of the use of bioprinted tissue constructs and/or regenerative medicine strategies the treatment of obstetric, gynecologic, and pediatric conditions?

This field is in its infancy but early clinical work using fetal valvuloplasty to treat valvular stenosis and reverse ventricular hypoplasia demonstrate proof-of-principle.

2. Where are we going? What bold application of bioprinted tissue construct and/or regenerative medicine solutions would you like to see in the treatment of obstetric, gynecologic, and pediatric conditions?

Using a regenerative medicine approach to repair an anomalous valve can not only restore valve function but also restore normal hemodynamics which in turn restore normal ventricular development.

3. Why are we not there yet? What are the major gaps and/or impediments (i.e., fundamental knowledge, technological, biological, regulatory, need for validated models/tools/biomarkers, clinical grade manufacturing, scale-up, financial, etc.) to the successful implementation of bioprinted tissue construct and/or regenerative

Development of new tools (i.e catheter based delivery systems, stents, and scaffolds) will be critical to this endeavor.

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Idea No. 239