Understanding the placenta from the cell unit constitution and the detailed cell diversity using new tools such as single cell approaches. The complexity of placental functions as a result of the integrated interaction between all trophoblasts subtypes, there is a big gap on the knowledge regarding the exact placental cellular diversity and individual functions (functional nodes). What we know so far and which are the available tools for addressing such unsolved questions?
A1. Identify the most significant recent achievements (technical/understanding) that position the field to gain a deeper understanding of human placenta development and function and support their advancement.
A2. Address the key knowledge gaps that hinder our capability to understand placenta development and function across pregnancy within the maternal/fetal/placenta ecosystem.
A4. Provide solutions to the key technology challenges that hinder advancing understanding of human placenta development and function.
A5. Leverage novel models that offer unique opportunities for generating new biological insights. (organoids, multi-component integrated tissue on a chip systems, iPSCs, etc.)