The Human Placenta Project

Placental Inflammation

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Placental inflammation is a key driver of adverse pregnancy events and also directly impacts fetal and neonatal development. A key focus on how inflammatory cells orchestrate immune tolerance and immunity to infection in healthy human placentas as well as how events including infection and allogeneic inflammatory responses contribute to failed trophoblast invasion, placental inflammation and pregnancy complications should be a key topic in basic placental research. A focus on human pregnancy is essential here as animal models lack key placental immune genes including HLA-G and HLA-C and do not recapitulate the KIR, MHC and memory T cell diversity as found in humans.

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Idea No. 58