The Human Placenta Project

Integrated study of placenta and pregnancy, towards personalized medicine

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Unlike any other pathologies, adverse pregnancy can be captured from its inception to its conclusion as these are well-defined start and endpoints. Additionally, pregnancy occurs in a defined time frame lasting less than a year (<42 weeks). Nearly all other pathologies develop over years or decades. Relative to other extensive population studies like the Framingham heart study following pregnancy from conception to delivery to identify variables predictive of outcomes is on a much more compressed time scale, reducing monitoring costs and following up and reaching results in a faster time frame. The project would ideally be conducted at a series of locations with different modality specialties. These may span many topics discussed at HPP meetings, from genomics, imaging, blood markers, histopathology and clinical variables (blood pressure, sleep cycles, weight gain/loss) through socioeconomic data and wellness. Outcome variables about the delivery and neonatal health will be crucial to interpretation. A prospective study design that includes follow-up over the first two months post-partum will capture rarer pathologies such as post-partum preeclampsia. Not all variables need to be collected at each study site, but more than one mode of analysis is required at each location. Overlapping modes of analysis can bridge data sets by matching between study sites. Unifying modes of analysis should enable clustering of the cohort based on maternal and placental/fetal characteristics recognizing their independence to the health and pathology of pregnancy. The project's goal would be to build optimized or personalize medicine approaches to pregnancy disease. This approach will enable better stratification of patients for intervention studies and ensure improved inclusion of underrepresented demographics.

Which theme and set of objectives does your response address? GENERAL FEEDBACK: New Research Theme or Objective

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