The Human Placenta Project

Human Umbilical Cord Development

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Very little is known about development of the human umbilical cord and insertion into the fetal abdominal wall, yet developmental abnormalities contribute to multiple recurring embryonic malformations, including limb-body wall complex, pentalogy of Cantrell and OEIS (omphalocele, exstrophy of bladder or cloaca, imperforate anus, and spinal defects). In addition, anomalies are more frequently associated with a two vessel (single umbilical artery) cord. There are also cases of persistent vitelline artery in conditions such as sirenomelia. Finding a suitable animal model and controlling for possible metabolic/nutritional causes of abnormal cord development could provide insight into potential prevention of these recurring developmental abnormalities

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

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