The Human Placenta Project

Basic Research Premeeting Discussion Summary - L Myatt & Y Sadovsky trending idea

Please provide your feedback: :

Key Achievements/Breakthroughs

• Development of trophoblast and decidual organoids

• Induced pluripotent stem cells

• Introduction of single cell and spatial technology to probe placental biology

• Appreciation of the roles of extracellular vesicles and the development of tools to probe their mechanism of action and function

• Advances in "omics" technologies and integration of "omic" data

• Emergence of microfluidic multicellular systems to capture villus biology

• Appreciation of sexual dimorphism in placental biology/function

Gaps in Knowledge

• Deeper insights into pre-pregnancy, pre-implantation and blastocyst biology and early placental development

• Immune interactions at the placenta-decidual interface

• A lack of broad high dimensional placental data sets across gestation, similar to the Cancer Atlas

• The impact of race/ethnicity/age/socioeconomic status/environment on placental development and function

• Tools to predict long term impact on child and adult health and wellness

Challenges

• Histopathology standards are not sensitive enough to delineate disease pathogenesis and differentiate clinical entities, particularly considering tissue availability only upon delivery

• Integration of placental biology, imaging and epidemiology and deep phenotyping of gestational health

• Deployment of complex and expensive imaging modalities to define placental function across pregnancy

• Organoids remain technically cumbersome and not widely accessible

• The knowledge in the extracellular vesicles landscape has not been deep enough for proper definitions of vesicle types, action, and regulation

• Inadequately standardized protocols for tissue collection and storage with flexibility to adapt to needs of emerging technologies

• A lack of agreed upon standardized data dictionaries for collection and recording of clinical data to facilitate comparison and data aggregation

• Engagement and interaction of basic scientists, bioinformaticians, engineers, and other disciplines into study of the placenta

• The translation of basic mechanisms to diagnostics, therapeutics, disease prevention

Opportunities

• Bolster the field of placental histopathology with molecular diagnostics

• Further the success of organoid cultures including establishing accessible organoids that capture the maternal-fetal interface across all three trimesters

• Refine the use of iPSC to build models and study trophoblast biology and interactions with other villous and extravillous cell types

• Study and define basic placental immunology and its relationship to successful establishment of pregnancy and to adverse outcomes

• Integration of omics and clinical data to advance knowledge on trajectories of a healthy pregnancy, and shed insight on problems even prior to clinical manifestations

• Utilize artificial intelligence and machine learning approaches to build phenotypes that link placental development and function across pregnancy

• Develop and utilize cutting edge tools for the use of animal models, such as guinea pig, marmoset monkey

• Collection and phenotyping of placentas that represent rare biology or pathology and comparison of extreme phenotypes, and making them accessible to all researchers

Which theme and set of objectives does your response address? THEME A: Basic Placenta Research

Tags

Annotations

Voting

8 votes
Ideate
Idea No. 114